Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. [...]
A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent
Diffuse intrinsic pontine gliomas (DIPGs) represent a particularly lethal type [...]
An Integrated Approach to Anti-Cancer Drug Sensitivity Prediction
A framework for design of personalized cancer therapy requires the [...]
Inference of dynamic biological networks based on responses to drug perturbations
Drugs that target specific proteins are a major paradigm in [...]
Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma
Alveolar rhabdomyosarcoma (aRMS) is a myogenic childhood sarcoma frequently associated [...]
A new approach for prediction of tumor sensitivity to targeted drugs based on functional data
The success of targeted anti-cancer drugs are frequently hindered by [...]
A kinase inhibition map approach for tumor sensitivity prediction and combination therapy design for targeted drugs
Drugs targeting specific kinases are becoming common in cancer research [...]
Generation of intervention strategy for a genetic regulatory network represented by a family of Markov Chains
Genetic Regulatory Networks (GRNs) are frequently modeled as Markov Chains [...]