Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma
Cancer patients with advanced disease routinely exhaust available clinical regimens [...]
Probabilistic modeling of personalized drug combinations
Probabilistic modeling of personalized drug combinations from integrated chemical screen [...]
Preclinical rationale for entinostat in embryonal rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in [...]
Elucidating the transcriptional program of feline injection-site sarcoma using a cross-species mRNA-sequencing approach
Feline injection-site sarcoma (FISS), an aggressive iatrogenic subcutaneous malignancy, is [...]
The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of [...]
IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma (DIPG) is a universally fatal childhood [...]
Integration of genomic, transcriptomic and functional profiles of aggressive osteosarcomas across multiple species
In complex, highly unstable genomes such as in osteosarcoma, targeting [...]
Preclinical testing of the glycogen synthase kinase-3β inhibitor tideglusib for rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. [...]
Combination therapy design for maximizing sensitivity and minimizing toxicity
Design of personalized targeted therapies involve modeling of patient sensitivity [...]
Target Inhibition Maps Based on Responses to Kinase Inhibitors
The prediction of tumor sensitivity to targeted drugs remains a [...]